Differentiated high-grade thyroid carcinoma (DHGTC) has a high mitotic count (≥5 mitoses per 2mm2) and/or tumor necrosis without anaplastic features. These tumors are rare, and the prevalence is not yet established among thyroid malignancies. BRAF and RAS mutations are the main driver mutations in these tumors. We present a case of a 43-year-old woman with DHGTC and NRAS mutation, presenting with metastatic follicular component to the bone and papillary component to lymph nodes.
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Moreno et al. (2022) studied this question.
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