Key result
Atherogenic index of plasma and resting Pd/Pa were independent predictors of functionally significant coronary artery stenosis (p=0.010 and p<0.001, respectively).
Why the study?
The study aimed to evaluate the relationship between the atherogenic index of plasma and resting distal-to-aortic pressure ratio in patients with intermediate coronary artery stenosis.
Do the atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) predict functionally significant coronary artery stenosis in patients with chronic coronary syndrome?
Observational (n=802)
Do the atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) predict functionally significant coronary artery stenosis in patients with chronic coronary syndrome?
The atherogenic index of plasma and resting Pd/Pa are independent predictors of functionally significant coronary stenosis, which may help identify patients with substantial atherosclerotic burden.
Resting Pd/Pa inversely associated with AIP in intermediate stenosis; hypothesis-generating and should not yet change practice.
This study aimed to assess the relationship between the atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) in patients with intermediate coronary artery stenosis. This retrospective study included 802 chronic coronary syndrome patients with intermediate coronary artery stenosis who underwent fractional flow reserve (FFR) measurement. The resting Pd/Pa showed a significant negative correlation with AIP (rho= -.205, p < .001). When final FFR was divided into three tertiles (≤80, 81-89, ≥90), resting Pd/Pa was significantly lower, and AIP was markedly higher in the lower final FFR tertiles (both AIP and resting Pd/Pa differed significantly across the all three tertiles, p < .001). Furthermore, functionally significant stenosis independent predictors in multivariate analyses were AIP and resting Pd/Pa (p = .010 and p < .001, respectively). We observed for the first time an increase in AIP levels in the presence of functionally significant stenoses that may help better planning and identification of those patients with the functionally substantial atherosclerotic burden.
No takes yet. Share an insight, caveat, or question.
Balcı et al. (2022) conducted an observational in Chronic coronary syndrome with intermediate coronary artery stenosis (n=802). Atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) was evaluated on Functionally significant stenosis (p=0.010 and <0.001). Atherogenic index of plasma and resting Pd/Pa were independent predictors of functionally significant coronary artery stenosis (p=0.010 and p<0.001, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: