Why the study?
Does increasing K+ to 12 mM inhibit spontaneous contractions and reduce myosin accumulation in cultured chick myotubes?
Population
Cultured developing chick myotubes
Comparison
Increasing K+ to 12 mM in the culture medium vs 5.4 mM K+ in the culture medium
Design
Preclinical
Authors
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Suppressing activity increases myosin turnover in chick myotubes; leaves open whether contractile dependence extends to mammalian or human muscle.
Does increasing K+ to 12 mM inhibit spontaneous contractions and reduce myosin accumulation in cultured chick myotubes?
Suppressed electrical or contractile activity in cultured myotubes via elevated potassium leads to increased myofibrillar protein turnover, indicating that spontaneous activity is required for continued myotube maturation.
Bandman et al. (1982) studied this question.
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