Assessing the Mechanisms That Give Rise to Autoimmunity

I read with great interest the report by Kouskoff et al . ([1][1]), in which the authors used an immunoglobulin M (IgM) nonswitchable B cell transgenic (Tg) mouse to show that the B cells could be made to react against a phage exhibiting a cross-reactive antigenic determinant of 20 amino acids in a