ADVANCES in our knowledge of the physiology of estrous and menstrual cycles have been hampered by a lack of reliable, quantitative methods for the detection and assay of progesterone in small amounts of blood. Methods for the measurement of pregnandiol and other excretory metabolites of progesterone have been useful but are of limited quantitative value and are not suitable to all species of mammals (Pincus, 1948). The bio-assay technique recently devised by Hooker and Forbes (1947) seems to fulfill the requirements of a quantitative micro-method and at the same time is apparently specific for progesterone and thus obviating the presence of other steroid hormones that may be in the test material (Hooker and Forbes, 1949). Therefore, this procedure was used in the present investigation. The purpose of this study was to determine the time of appearance and the amount of progesterone in the blood serum of normal adult monkeys (Macaca mulatta) during the menstrual cycle.
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Fred E. Bryans (1951) studied this question.