Why the study?
Does low heart rate variability predict the progression of coronary atherosclerosis in patients with prior CABG and low HDL-C?
Population
265 patients with prior coronary artery bypass surgery and low high-density lipoprotein cholesterol…
Comparison
Low heart rate variability measured by 12-hour… vs Higher heart rate variability
Design
Cohort, Patients were randomized to receive a placebo or gemfibrozil therapy…
Follow-up
average 32 months
Authors
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Low SDNN was associated with faster post-CABG atherosclerosis progression; supports HRV as prognostic marker but leaves open therapeutic implications.
Does low heart rate variability predict the progression of coronary atherosclerosis in patients with prior CABG and low HDL-C?
Low heart rate variability independently predicts rapid angiographic progression of coronary artery disease in patients with prior CABG, providing prognostic information beyond traditional risk markers.
Huikuri et al. (1999) studied this question.
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