What question did this study set out to answer?

To assess whether circulating cytokine levels, particularly IL-6 and IL-10, correlate with a history of lifetime suicide attempts among individuals undergoing treatment for alcohol use disorder.

October 1, 2023Neuropsychiatric Disease and TreatmentOpen Access

Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients

View Full Paper

Ask AI

Bookmark

Authors

JBJørgen G. BramnessOslo University Hospital SPSusmita PandeyInnlandet Hospital Trust JMJenny Skumsnes MoeInnlandet Hospital Trust

Discussion

Member takes

Implication

Observational study finds elevated interleukin-6 levels linked to lifetime suicide attempts in alcohol use disorder patients, highlighting systemic inflammation's role in psychiatric risk.

Key Points

To assess whether circulating cytokine levels, particularly IL-6 and IL-10, correlate with a history of lifetime suicide attempts among individuals undergoing treatment for alcohol use disorder.
Conducted a naturalistic observational study of 114 patients admitted to residential treatment for alcohol use disorder.
Assessed lifetime suicide attempts, affective symptoms, and clinical severity via structured clinical interviews.
Measured serum cytokine concentrations and evaluated associations using bivariate analyses and multivariate linear regression adjusting for sex, nicotine use, somatic illness, and anti-inflammatory medication.
Thirty-one patients (27%) reported at least one lifetime suicide attempt, displaying higher levels of affective disorder symptoms and more severe alcohol dependence.
Multivariate linear regression identified a significant association between elevated IL-6 concentrations and lifetime suicide attempts (p = 0.033) after controlling for clinical and demographic covariates.

Cite This Study

Bramness et al. (2023) studied this question.

synapsesocial.com/papers/6a7aa87d2eb3c7e469f41516 https://doi.org/10.2147/ndt.s413101

View Full Paper

Ask AI

Bookmark

Implication

Observational study finds elevated interleukin-6 levels linked to lifetime suicide attempts in alcohol use disorder patients, highlighting systemic inflammation's role in psychiatric risk.

Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider