Polycystic ovary syndrome is increasingly understood as a disorder of intermediary metabolism characterized by insulin resistance, which has implications for general well-being and novel treatments.
May inform metabolic evaluation in PCOS care; leaves open efficacy of targeted interventions.
Polycystic ovary syndrome is one of the most common endocrinopathies worldwide and for many years it was one of the most difficult to elucidate. In the last 10 years, understanding of this condition has increased greatly. It is now clear that polycystic ovary syndrome is not an ovarian disease, rather it is a disorder of intermediary metabolism characterized by insulin resistance. It has also become clear that insulin resistance has implications for general well-being and for the development of novel treatments.
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Fox et al. (2002) studied this question.
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