November 1, 1988Pacing and Clinical Electrophysiology

Physiological Principles of a New Method for Rate Responsive Pacing Using the Pre‐ejection Interval

View Full Paper

Ask AI

Bookmark

Why the study?

Is the pre-ejection interval (PEI) a suitable physiological parameter for rate-responsive pacing?

Population

30 patients, including a subset with complete AV block

Comparison

Measurement of pre-ejection interval during… vs Simultaneous atrial rate

Design

Other

Authors

RCRaúl ChirifeTufts University

Discussion

Member takes

Implication

Supports PEI as potential sensor for rate-responsive pacing; hypothesis-generating and requires prospective device trials.

Structured PICO

Is the pre-ejection interval (PEI) a suitable physiological parameter for rate-responsive pacing?

Population

30 patients, including a subset with complete AV block

Intervention

Measurement of pre-ejection interval (PEI) during isotonic and isometric exercise, emotional stress, isoproterenol infusion, Valsalva maneuver, carotid massage, atropine injection, and incremental pacing

Comparator

Simultaneous atrial rate (in patients with complete AV block)

Outcome

Changes in PEI (sensitivity, specificity, proportionality, and speed of response)surrogate

The pre-ejection interval responds proportionately to sympathetic stress and is unaffected by preload or parasympathetic tone, making it a suitable parameter for rate-responsive pacing.

Cite This Study

Raúl Chirife (1988) studied this question.

synapsesocial.com/papers/6a7ab65b4c448619ca0e45e1 https://doi.org/10.1111/j.1540-8159.1988.tb06272.x

View Full Paper

Ask AI

Bookmark