Why the study?
Reflected pressure wave metrics index vascular ageing, but the extent to which these indices are influenced by factors other than vascular health remains a concern.
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Design
Mathematical modeling study using transmission-line theory
Wave reflection indices may be confounded by non-vascular factors clinically; leaves open their reliability as vascular ageing markers pending validation.
Reflected pressure waves are key to the understanding of vascular ageing, a prominent factor in major cardiovascular events. Several different metrics have been proposed to index the effect of wave reflection on the pressure waveform and thereby serve as an indicator of vascular ageing. The extent to which these indices are influenced by factors other than vascular health remains a matter of concern. In this paper, we use transmission-line theory to derive a mathematical model for the reflection time (T refl ), and the augmentation index (AI), assuming a general extended model of the arterial system. Then, we test the proposed model against values reported in the literature. Finally, we discuss insights from the model to common observations in the literature such as age-related “shift” in the reflection site, the variation of AI with heart rate, and the flattening of T refl in older participants.
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Afkhami et al. (2020) studied this question.
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