thereby permitting the fairly confident exclusion of hypertension as such as the precipitating factor. It was considered possible that phenobarbitone present in the serum might interfere with the laboratory procedure and result in artificially low oestriol values, but this was discounted after evidence showed that the behaviour of the assay was not appreciably affected by the in-vitro addition of phenobarbitone in amounts considerably above those reached during normal treatment.
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Ruddell et al. (1980) studied this question.