Analgesic and anti-inflammatory activities of Annona squamosa Linn bark

Caryophyllene oxide was isolated from a methanolic extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25 mg/kg body wt. and methanol extract at a dose of 50 mg/kg body wt. showed significant central as we as peripheral analgesic along with anti-inflammatory activity. These activities of caryophyllene oxide were comparable with the standard drug Pentazocin (50 mg/kg body wt.) for Anti-inflammatory activities and Aspirin (100 mg/kg body wt.) for Analgesic activity used in the respective experiments.