Microreactor Technology: Continuous Synthesis of 1H-Isochromeno[3,4-d]imidazol-5-ones

A synthetic method was evaluated to form 1 H -isochromeno[3,4- d ]imidazol-5-ones via ring closure starting from 3-amino-4-(arylamino)-1 H -isochromen-1-ones. The method was implemented and optimized in a microreactor environment. It was possible to synthesize these compounds in a continuous mode with an output up to 2.2 g/h.