Systematic review identifies genetic and environmental factors linked to developmental dysplasia of the hip in Gulf nations, suggesting a multifactorial etiology.
Key Points
The aim is to describe genetic determinants related to developmental dysplasia of the hip (DDH) in Saudi Arabia and Gulf nations.
Literature search conducted in PubMed, Embase, Scopus, Web of Science, and other databases until 2023.
Included studies focused on genetic factors influencing DDH in Saudi Arabia and Gulf countries.
Data extracted and summarized qualitatively due to variations in study design and genetic methods.
Out of 473 articles retrieved, 11 were selected that correlated DDH with genetic factors.
Significant associations were found with rare variants in HSPG2 and ATP2B4 and polymorphisms in growth/differentiation factor 5.
Findings indicated high familial clustering and a potential interaction between genetic susceptibility and environmental factors.