The inverse quadrupolar moments of the phenyl and pentafluorophenyl residues in the non-hydrogen-bonded, artificial base pair shown here promotes strong intramolecular stacking interactions in oligonucleotide duplexes. The greater the number of natural base pairs that are replaced by this novel pair, the higher the thermodynamic stability of the resulting oligonucleotide duplex if they are arranged in an alternating fashion.
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Mathis et al. (2002) studied this question.
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