This review discusses the development and future directions of designer natriuretic peptides engineered to optimize pharmacological actions and minimize undesirable effects.
Designer natriuretic peptides remain investigational; this review extends preclinical concepts but leaves clinical translation open.
Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed.
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Lee et al. (2009) studied this question.
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