This first human autopsy case confirms that cryoballoon ablation lesions are more clearly delineated and uniformly replaced with fibrous tissue compared to radiofrequency lesions.
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First human autopsy validation of cryoballoon lesions; extends animal data but leaves open clinical translation.
Key Teaching Points•The histologic changes of the left atrium and pulmonary vein after cryoballoon ablation were observed for the first time in a human autopsy case. The autopsy findings confirmed that the lesion formed after cryoballoon ablation in an 82-year-old woman was similar to those observed in the canine model.•The radiofrequency lesion at the cavotricuspid isthmus of the right atrium was unclearly demarcated from the normal myocardium. The dense fibrous tissue was thinner, and the lesion was shallower than the cryoballoon lesion.•The cryoablation lesion had less endocardial bleeding, was more clearly delineated, and had been more uniformly replaced with fibrous tissue than the lesion of the cavotricuspid isthmus. •The histologic changes of the left atrium and pulmonary vein after cryoballoon ablation were observed for the first time in a human autopsy case. The autopsy findings confirmed that the lesion formed after cryoballoon ablation in an 82-year-old woman was similar to those observed in the canine model.•The radiofrequency lesion at the cavotricuspid isthmus of the right atrium was unclearly demarcated from the normal myocardium. The dense fibrous tissue was thinner, and the lesion was shallower than the cryoballoon lesion.•The cryoablation lesion had less endocardial bleeding, was more clearly delineated, and had been more uniformly replaced with fibrous tissue than the lesion of the cavotricuspid isthmus.
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Hirao et al. (2018) studied this question.
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