Key result
Administration of ω-3 fatty acids significantly decreased MDA levels and increased GSH, SOD, and GSH-Px activities in serum, liver, and kidney tissues of rats exposed to doxorubicin.
Why the study?
Does omega-3 fatty acid supplementation prevent doxorubicin-induced hepatotoxicity and nephrotoxicity in rats?
Population
24 adult male Sprague Dawley rats
Comparison
Omega-3 fatty acids 400 mg/kg daily by… vs Doxorubicin alone and saline control
Design
Preclinical
Follow-up
30 days
Authors
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Hypothesis-generating for omega-3 against doxorubicin oxidative damage in rats; leaves open any human translation and should not alter practice.
Does omega-3 fatty acid supplementation prevent doxorubicin-induced hepatotoxicity and nephrotoxicity in rats?
Omega-3 fatty acids may protect against doxorubicin-induced oxidative damage in liver and kidney tissues in a rat model.
Tülübaş et al. (2013) studied Doxorubicin-induced hepatotoxicity and nephrotoxicity (n=24). ω-3 fatty acids vs. Doxorubicin alone and saline control was evaluated on Glutathione (GSH) and malondialdehyde (MDA) levels in serum, and GSH, MDA, SOD, and GSH-Px activities in liver and kidney tissues. Administration of ω-3 fatty acids significantly decreased MDA levels and increased GSH, SOD, and GSH-Px activities in serum, liver, and kidney tissues of rats exposed to doxorubicin.
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