Population
Normal CD-1 mice
Comparison
Intravenous injection of trace amounts of… vs 125I-rmTPO alone
Design
Preclinical
Follow-up
2 hours postinjection
Authors
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Saturable c-Mpl binding governs TPO clearance in vivo; extends mechanistic models but leaves open human translation.
In vivo, TPO is mainly metabolized by platelets and to a small extent by megakaryocyte lineage cells via a specific and saturable mechanism with an affinity of ~6.4 microg/kg.
Stefanich et al. (1997) studied this question.
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