Changes in the Connective Tissue and Inflammatory Response to Ehrlich's Carcinoma Following Treatment of the Host Mice With Butazolidine

A changed growth pattern is reported in subcutaneous transplants of Ehrlich's carcinoma in mice following systemic treatment with Butazolidine. An acute inflammatory response was seen at the edge of the tumour transplant in the untreated control mice. Treatment with Butazolidine favoured the development of denser connective tissue which ran along the edge of the transplant rather than mingling with it. The change in the orientation of the fibroblasts and capillaries was accompanied by an increase in lymphocyte and macrophage infiltration and tumour cell necrosis. It is suggested that the tumour's ability to induce an acute inflammatory response may be a prerequisite for stroma formation and vital to the establishment of infiltrative growth.