Tetrandrine Inhibits Breakdown of Blood-Aqueous Barrier Induced by Endotoxin and Interleukin-1α in Rats

Tetrandrine was shown to significantly inhibit uveitis induced by endotoxin and interleukin-1 alpha (IL-1 alpha) in rats. The dose-response curve of IL-1 alpha-induced uveitis was inhibited in a non-competitive manner. The maximum inflammation induced by IL-1 alpha was suppressed to 58.4%, 38.3% and 18.3% of the control peak by 5 mg/kg, 10 mg/kg and 20 mg/kg t.i.d. of tetrandrine, respectively. The maximum inflammation induced by endotoxin was suppressed to 56.5% and 38.0% by 5 mg/kg and 10 mg/kg t.i.d. of tetrandrine, respectively. The mechanism of tetrandrine's anti-inflammation could involve numerous pathways of inflammation processes and multiple inflammatory mediators. The results of this study indicate that tetrandrine appears to be a broad spectrum, non-steroidal, novel ocular anti-inflammatory agent.