Understanding the MIG6–EGFR Signaling Axis in Lung Tumorigenesis

Summary: With multiple clinical trials under way targeting mutant EGFR in patients with lung cancer, Maity and colleagues address important aspects of a MIG6–EGFR signaling axis using genetically engineered mouse models expressing mutated EGFRs on the MIG6-deficient background. This study extends our understanding of EGFR regulation by MIG6 and reveals that MIG6 antagonizes tumor formation in mutant EGFR–driven lung adenocarcinoma. Cancer Discov; 5(5); 472–4.