The efficient large-scale synthesis (see below) of an enantiomerically pure Taxol side chain precursor—3-phenylisoserine (1)—highlights the potential of the third modification of the asymmetric aminohydroxylation (AA). The use of N-bromoacetamide as the nitrogen source is the latest advance in the osmium-catalyzed AA of olefins.
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Bruncko et al. (1997) studied this question.
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