June 30, 2009Journal of Cardiovascular Electrophysiology
Feasibility and Safety of Using an Esophageal Protective System to Eliminate Esophageal Thermal Injury: Implications on Atrial‐Esophageal Fistula Following AF Ablation
Key result
An esophageal protective system circulating fluid at 5 or 10 degrees C spared the esophagus from collateral thermal injury during RF ablation in a canine model.
Why the study?
Does an esophageal protective system (EPSac) prevent esophageal thermal injury during RF ablation in preclinical models?
Population
In vitro heart-esophagus preparation and 6 closed-chest dogs
Comparison
Temperature-controlled fluid-circulating… vs RF ablation without EPSac (control)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports clinical testing of esophageal cooling during RF ablation; leaves open translation from canine model to patients.
Structured PICO
Does an esophageal protective system (EPSac) prevent esophageal thermal injury during RF ablation in preclinical models?
P
Population
In vitro heart-esophagus preparation and 6 closed chest dogs undergoing RF ablation.
I
Intervention
Temperature-controlled fluid-circulating esophageal protective system (EPSac) with an expandable compliant sac during cardiac RF delivery, tested at 25, 15, 10, and 5 degrees C
C
Comparator
RF ablation without EPSac (control)
O
Outcome
Esophageal thermal injurysafety
An esophageal protective system circulating fluid at 5 or 10 degrees C successfully prevented collateral esophageal thermal injury during RF ablation in a preclinical canine model.
Limitations
- Its safety and efficacy remain to be demonstrated in patients undergoing AF ablation.
- Safety and efficacy remain to be demonstrated in patients undergoing AF ablation
Cite This Study
Arruda et al. (2009) studied Atrial fibrillation ablation (pre-clinical model) (n=6). Esophageal protective system (EPSac) vs. Without EPSac (control) or EPSac at 25 degrees C was evaluated on Esophageal thermal injury. An esophageal protective system circulating fluid at 5 or 10 degrees C spared the esophagus from collateral thermal injury during RF ablation in a canine model.