Why the study?
Does clopidogrel reduce recurrent ischaemic events in patients with recent ischaemic stroke, recent myocardial infarction (MI), or peripheral arterial disease and previous cardiac surgery compared to aspirin?
Does clopidogrel reduce recurrent ischaemic events in patients with recent ischaemic stroke, recent myocardial infarction (MI), or peripheral arterial disease and previous cardiac surgery compared to aspirin?
In patients with prior cardiac surgery and recent ischemic events or peripheral arterial disease, clopidogrel is more effective than aspirin in reducing recurrent ischemic events.
Clopidogrel may be preferred over aspirin post-cardiac surgery; extends RCT evidence to this high-risk subgroup.
(2001) Circulation 103, 363. Bhatt DL, Chew DP, Hirsch AT, et al. . Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery. . Jan 23; . : . –8 . [OpenUrl][1][Abstract/FREE Full Text][2] QUESTION: In patients with recent ischaemic stroke, recent myocardial infarction (MI), or peripheral arterial disease and previous cardiac surgery, is clopidogrel more effective than aspirin in reducing recurrent ischaemic events? Subgroup analysis of a randomised {allocation concealed*}†, blinded {patients, clinicians, outcome assessors, and statisticians}†* placebo controlled trial with 1–3 year follow up (mean 1.6 y) (Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events [CAPRIE] study). {384 clinical centres in 16 countries}†. 1480 patients (mean age 64 y, 84% men, 96% white) with recent stroke or MI or peripheral arterial disease who … [1]: {openurl}?query=rft.jtitle%253DCirculation%26rft.stitle%253DCirculation%26rft.issn%253D0009-7322%26rft.aulast%253DBhatt%26rft.auinit1%253DD.%2BL.%26rft.volume%253D103%26rft.issue%253D3%26rft.spage%253D363%26rft.epage%253D368%26rft.atitle%253DSuperiority%2Bof%2BClopidogrel%2BVersus%2BAspirin%2Bin%2BPatients%2BWith%2BPrior%2BCardiac%2BSurgery%26rft_id%253Dinfo%253Adoi%252F10.1161%252F01.CIR.103.3.363%26rft_id%253Dinfo%253Apmid%252F11157686%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=circulationaha&resid=103/3/363&atom=%2Febmed%2F6%2F4%2F114.atom
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BMJ Publishing Group Ltd (2001) studied this question.
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