June 1, 1998HypertensionOpen Access

Angiotensin II Induces Vascular Smooth Muscle Cell Replication Independent of Blood Pressure

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Why the study?

Does Angiotensin II induce vascular smooth muscle cell replication independent of its blood pressure-raising effects in rats?

Population

Rats (in vivo model evaluating mesenteric vessels and carotid arteries)

Comparison

Angiotensin II infusion with hydralazine to… vs Angiotensin II infusion alone

Design

Preclinical

Follow-up

1 week

Authors

ESEnming J. SuUniversity of Michigan DLDonna M. LombardiUniversity of Washington JSJustin A. SiegalSaint Louis University

Discussion

Member takes

Implication

Ang II may drive VSMC proliferation independent of BP in rats; hypothesis-generating and should not yet inform clinical practice.

Structured PICO

Does Angiotensin II induce vascular smooth muscle cell replication independent of its blood pressure-raising effects in rats?

Population

Rats (in vivo model evaluating mesenteric vessels and carotid arteries)

Intervention

Angiotensin II infusion (435 ng/kg/min) with hydralazine to normalize blood pressure

Comparator

Angiotensin II infusion alone (which raises systolic blood pressure from 120 to 200 mm Hg)

Outcome

Vascular smooth muscle cell proliferation/replicationsurrogate

Angiotensin II directly stimulates vascular smooth muscle cell proliferation independent of its hypertensive effects.

Cite This Study

Su et al. (1998) studied this question.

synapsesocial.com/papers/6a7b6be4e357fbdac589dd27 https://doi.org/10.1161/01.hyp.31.6.1331

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Angiotensin II Induces Vascular Smooth Muscle Cell Replication Independent of Blood Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Induces Vascular Smooth Muscle Cell Replication Independent of Blood Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider