Key result
Pulmonary artery denervation is a safe, minimally invasive procedure that demonstrates beneficial effects on both hemodynamic and clinical parameters in patients with pulmonary hypertension.
Why the study?
Despite treatment advances, the prognosis of patients with primary and secondary pulmonary hypertension remains unfavorable.
Does pulmonary artery denervation improve hemodynamic and clinical parameters in patients with pulmonary hypertension?
Does pulmonary artery denervation improve hemodynamic and clinical parameters in patients with pulmonary hypertension?
Pulmonary artery denervation is a promising, minimally invasive treatment for pulmonary hypertension that shows potential in improving hemodynamics and exercise capacity, though further research is needed to refine the technique and patient selection.
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Pulmonary artery denervation may warrant study in PH; leaves open its clinical role pending controlled trials.
Despite treatment advances, the prognosis of patients with both primary and secondary pulmonary hypertension (PH) remains unfavorable. The increased activity of the sympathetic nervous system is one of the universal mechanisms involved in the PH pathogenesis. Pulmonary artery denervation is a novel minimally invasive pathogenetic method of PH treatment. The denervation procedure is mainly implemented by using radiofrequency ablation of the pulmonary trunk, where most sympathetic nerve fibers are located. In this article we present an overview and analysis of the present state, results of various experimental and clinical studies, as well as clinical experience. The results of studies demonstrated the safety of endovascular surgery and its beneficial effect on both hemodynamic and clinical parameters.
Feshchenko et al. (2019) conducted a review in Pulmonary hypertension. Pulmonary artery denervation was evaluated. Pulmonary artery denervation is a safe, minimally invasive procedure that demonstrates beneficial effects on both hemodynamic and clinical parameters in patients with pulmonary hypertension.