Key result
Targeted ultrasound delivery of 10^8 rapamycin microbubbles reduced neointima formation by 35.9% compared to 0% without ultrasound, achieving effects similar to a 10-fold higher dose.
Why the study?
Does targeted ultrasound delivery of rapamycin microbubbles reduce the drug dose necessary to inhibit neointima formation in a rat carotid balloon injury model?
Does targeted ultrasound delivery of rapamycin microbubbles reduce the drug dose necessary to inhibit neointima formation in a rat carotid balloon injury model?
Ultrasound-mediated delivery of rapamycin microbubbles allows for a 10-fold reduction in the drug dose required to effectively inhibit neointima formation in a preclinical model.
May enable lower-dose rapamycin delivery to inhibit neointimal hyperplasia; hypothesis-generating for clinical restenosis prevention.
OBJECTIVE: We hypothesized that (1) neointima formation in a rat carotid balloon injury model could be reduced in vivo following targeted ultrasound delivery of rapamycin microbubbles (RMBs), and (2) the addition of dual-mode ultrasound decreases the total amount of drug needed to reduce neointima formation. METHODS AND RESULTS: Balloon injury was performed in rat carotids to induce neointima formation. High or low doses of RMBs were injected intravenously and ruptured at the site of injury with ultrasound. Compared with nontreated injured arteries, neointima formation was reduced by 0% and 35.9% with 10(8) RMBs and by 28.7% and 34.9% in arteries treated with 10(9) RMBs with and without ultrasound, respectively. CONCLUSIONS: Without ultrasound, 10-fold higher concentrations of RMBs were needed to reduce neointima formation by at least 28%, whereas 10(8) RMBs combined with ultrasound were sufficient to achieve the same therapeutic effect, demonstrating that this technology may have promise for localized potent drug therapy.
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Phillips et al. (2011) studied Neointima formation. Rapamycin microbubbles (RMBs) with targeted ultrasound vs. RMBs without ultrasound or nontreated injured arteries was evaluated on Reduction in neointima formation compared with nontreated injured arteries. Targeted ultrasound delivery of 10^8 rapamycin microbubbles reduced neointima formation by 35.9% compared to 0% without ultrasound, achieving effects similar to a 10-fold higher dose.
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