Key result
Cardiomyopathy cases globally increased by 41.5% from 1990 to 2019, despite a 0.5% decline in age-standardized prevalence rates, remaining a persistent threat to global public health.
Why the study?
The study was conducted to gauge the incidence of alcoholic cardiomyopathy and other cardiomyopathy across 204 nations and regions from 1990 to 2019.
Observational
Effect estimate: -0.5% change (95% CI -0.6 to -0.4)
The absolute global burden of alcoholic and other cardiomyopathies has increased from 1990 to 2019, emphasizing the need for improved surveillance and targeted public health interventions.
Global AC/OC burden estimates inform planning; leaves open etiology-specific prevention trials.
Objective : To gauge the incidence of both alcoholic cardiomyopathy (AC) and other cardiomyopathy (OC) in 204 nations and regions over the 1990 – 2019 period. Methods : The Global Burden of Disease Study 2019 was leveraged to gather comprehensive information pertaining to both AC and OC. The calculated prevalence rates, mortality rates, and disability-adjusted life years (DALYs) related to these forms of cardiomyopathy were presented as counts and age-standardized rates (ASRs) per 100,000 persons with percentage change and 95% uncertainty intervals (UIs). The overall burden of cardiomyopathy was established by combining data pertaining to both AC and OC, with calculations and corresponding 95% confidence intervals (CIs) being determined based upon corresponding standard error values determined by dividing the width of 95% UI by 1.96×2. Results : At the national level, ASR rates for cardiomyopathy varied by 144.6-fold among surveyed countries in 2019, while the rates ASR rates for AC and OC respectively varied by 408.0-fold and 380.6-fold. Age-standardized cardiomyopathy-associated mortality rates also varied by 58.4-fold among surveyed nations. The highest such AC-related death rates were observed in Latvia, with an age-standardized mortality rate of 16.3 (95%UI 11.0 to 21.1) per 100,000 persons, whereas some nations reported 0 AC-related deaths in 2019. National age-standardized OC-related mortality rates varied by 105-fold among surveyed nations. Despite overall reductions in cardiomyopathy ASRs from 1990 – 2019, the overall numbers of cases, deaths, years lost in life (YLLs), and years lost due to disability (YLDs) have all increased over this period for both AC and OC. Conclusion : These data suggest that cardiomyopathy, including both AC and OC, remains a persistent threat to global public health as evidenced by increased numbers of cases, deaths, and DALYs over the past three decades, with clear geographic differences in overall cardiomyopathy burden. Additional study will be essential to more fully understand the risk factors associated with the development of this disease in an effort to guide its prevention, early diagnosis, and treatment.
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Guo et al. (2022) conducted an observational in Cardiomyopathy (Alcoholic and Other). Alcoholic and other cardiomyopathy was evaluated on Percentage change in age-standardized prevalence rates of cardiomyopathy from 1990 to 2019 (-0.5% change, 95% CI -0.6 to -0.4). Cardiomyopathy cases globally increased by 41.5% from 1990 to 2019, despite a 0.5% decline in age-standardized prevalence rates, remaining a persistent threat to global public health.
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