Key result
Diabetes mellitus was an independent predictor of pulmonary hypertension in patients with chronic respiratory disease, increasing the odds of pulmonary hypertension by nearly threefold (OR 2.935).
Why the study?
Does the presence of diabetes mellitus predict pulmonary hypertension in patients with chronic respiratory disease?
Observational (n=386)
No
Does the presence of diabetes mellitus predict pulmonary hypertension in patients with chronic respiratory disease?
Diabetes mellitus is an independent predictor of pulmonary hypertension in patients with chronic respiratory disease, suggesting a need for heightened screening in this subgroup.
DM may predict PH in chronic respiratory disease; hypothesis-generating and requires prospective confirmation before practice change.
BACKGROUND: Pulmonary hypertension (PH) is a common complication of chronic respiratory disease. Recent studies have reported diabetes mellitus (DM) to be a poor prognostic factor in patients with chronic respiratory disease, including chronic obstructive pulmonary disease or interstitial pneumoniae. However, the association between DM and PH in chronic respiratory disease remains unclear. In this study, we aimed to investigate whether DM is a predictor of PH in patients with chronic respiratory disease. METHODS: We prospectively analyzed 386 patients in our hospital with chronic respiratory disease. An echocardiographic pressure gradient between the right atrium and the right ventricle of ≥ 40 mmHg was defined as PH. We compared the clinical characteristics and impact of DM between chronic respiratory disease patients with and those without PH. RESULTS: Of the 386 patients, 42 (10.9%) were diagnosed as having PH. The PH group had higher modified medical research council (mMRC) grade and complication rate of DM, but not hypertension and hyperlipidemia, when compared to the non-PH group. Multivariable logistic regression analysis revealed that mMRC scale (odds ratio 1.702, 95% confidence interval, 1.297 to 2.232, P < 0.001) and presence of DM (odd ratio 2.935, 95% confidence interval, 1.505 to 5.725, P = 0.002) were associated with PH in chronic respiratory disease patients. CONCLUSION: DM is potentially associated with PH and is an independent factor for prediction of PH in patients with chronic respiratory disease.
No takes yet. Share an insight, caveat, or question.
Takahashi et al. (2018) conducted an observational in Chronic respiratory disease (COPD or interstitial pneumonia) (n=386). Diabetes mellitus vs. Without diabetes mellitus was evaluated on Pulmonary hypertension (TR-PG ≥ 40 mmHg) (OR 2.935, 95% CI 1.505-5.725, p=0.002). Diabetes mellitus was an independent predictor of pulmonary hypertension in patients with chronic respiratory disease, increasing the odds of pulmonary hypertension by nearly threefold (OR 2.935).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: