Key result
Obesity significantly increased the risk of high blood pressure (OR 2.443) and prediabetes (OR 1.399) in first-degree relatives of patients with type 2 diabetes.
Why the study?
Prediabetes is strongly associated with high blood pressure, but little is known about their comorbidity in high-risk individuals such as first-degree relatives of type 2 diabetes mellitus patients.
Population
1388 nondiabetic first-degree relatives of T2DM patients
Design
Cohort study
Follow-up
9-year
Authors
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May inform risk monitoring in FDRs of T2DM; leaves open causal effects and need for trials.
Cohort (n=1,388)
No
Odds Ratio: 2.443 (95% CI 1.978–3.031)
Remnant-cholesterol, obesity, and age are significant longitudinal predictors of prediabetes, high blood pressure, and their coexistence in first-degree relatives of patients with type 2 diabetes.
Aminorroaya et al. (2020) conducted a cohort in Prediabetes and high blood pressure (n=1,388). Obesity vs. Non-obese participants was evaluated on High blood pressure (OR 2.443, 95% CI 1.978-3.031). Obesity significantly increased the risk of high blood pressure (OR 2.443) and prediabetes (OR 1.399) in first-degree relatives of patients with type 2 diabetes.
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