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Peptide hormones and neurotransmitters play an essential role in regulation of cellular metabolism. Once released from an endocrine cell or nerve ending, peptides encounter membrane-bound and soluble peptidases. The peptidases inactivate peptides or form fragments with novel biologic activity. Therefore, peptidases must play a major role in homeostatic control, but this aspect of regulation has been a neglected area. This review examines the postsecretory metabolism of biologically active peptides in the brain and alimentary tract, 2 organs in which peptide regulation is of crucial importance.
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Nigel W. Bunnett (1987) studied this question.
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