Key result
Intra-operative intravenous magnesium sulphate reduced maximum clot firmness on the third postoperative day compared with isotonic saline in colorectal cancer surgery patients (p < 0.05).
Why the study?
Does intravenous magnesium sulphate reduce blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery?
RCT (n=44)
randomly allocated
Does intravenous magnesium sulphate reduce blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery?
p-value: p=<0.05
Intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.
Supports intraoperative magnesium to mitigate hypercoagulability in colorectal cancer surgery; extends RCT hemostasis data to this population.
We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg(-1) followed by a continuous infusion of 15 mg.kg(-1) .h(-1) ), whereas the control group received the same volume of isotonic saline. Mean (SD) postoperative serum magnesium levels were 1.60 (0.13) mmol.l(-1) in the magnesium group compared with 0.98 (0.06) mmol.l(-1) in the control group (p < 0.001). All maximum clot firmness values of ROTEM analysis were significantly lower on the third postoperative day in the magnesium group compared with the control group (p < 0.05). We conclude that ROTEM analysis demonstrated that intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.
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Na et al. (2014) conducted an RCT in laparoscopic colorectal cancer surgery (n=44). magnesium sulphate vs. isotonic saline was evaluated on maximum clot firmness values of ROTEM analysis on the third postoperative day (p=<0.05). Intra-operative intravenous magnesium sulphate reduced maximum clot firmness on the third postoperative day compared with isotonic saline in colorectal cancer surgery patients (p < 0.05).
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