Key result
Quercetin co-treatment partially prevented cisplatin-induced renal toxicity, including decreased renal blood flow and tubular necrosis, without impairing its anti-tumour activity in rats.
Why the study?
Does quercetin prevent cisplatin-induced nephrotoxicity without affecting its anti-tumour activity in a rat tumour model?
Population
Male Fischer rats inoculated subcutaneously with breast adenocarcinoma (13762 Mat B-III) cells
Comparison
Quercetin 50 mg/kg/day intraperitoneally… vs Vehicle
Design
Preclinical
Follow-up
2 or 6 days after cisplatin administration
Authors
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Hypothesis-generating in rat models; leaves open clinical translation and human safety.
Does quercetin prevent cisplatin-induced nephrotoxicity without affecting its anti-tumour activity in a rat tumour model?
Quercetin may offer a protective strategy against cisplatin-induced nephrotoxicity without compromising chemotherapeutic efficacy, based on a preclinical rat model.
Sánchez‐González et al. (2011) studied Cisplatin nephrotoxicity. Quercetin vs. Vehicle was evaluated on Renal function, toxicity markers, and tumour growth. Quercetin co-treatment partially prevented cisplatin-induced renal toxicity, including decreased renal blood flow and tubular necrosis, without impairing its anti-tumour activity in rats.
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