Population
Individuals or models with insulin resistance and ovarian hyperandrogenism
Design
Review
Authors
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May guide selective PCOS therapies; leaves open molecular targets for ovarian androgen excess.
This review discusses the paradox of how the ovary remains sensitive to insulin and overproduces androgens in insulin-resistant states where other classical target organs do not respond normally.
Leonid Poretsky (1991) studied this question.
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