Brain endothelial cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway in aging and neurodegeneration

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This perspective aims to examine the role of the cGAS-STING signaling pathway in brain endothelial cells during aging and neurodegenerative diseases.
Review of existing literature on cGAS-STING signaling and endothelial function.
Analysis of inflammatory mechanisms in neurovascular systems during aging and neurodegeneration.
Discussion of therapeutic implications of cGAS-STING modulation in brain endothelial cells.
cGAS-STING pathway activation correlates with neuroinflammatory diseases, including Alzheimer's and aging-related conditions.
Inhibition of cGAS or STING improves endothelial function and reduces inflammation in aging models.
Elevated STING expression is observed in brain endothelial cells during neurodegenerative diseases.

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Perspective reviews the role of cGAS-STING signaling in endothelial inflammation and aging-related neurodegenerative diseases.

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Sun et al. (2024) studied this question.

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