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Abstract We report the rational design of metal–organic layers (MOLs) that are built from Hf 6 O 4 (OH) 4 (HCO 2 ) 6 secondary building units (SBUs) and Irbpy(ppy) 2 + ‐ or Ru(bpy) 3 2+ ‐derived tricarboxylate ligands (Hf‐BPY‐Ir or Hf‐BPY‐Ru; bpy=2,2′‐bipyridine, ppy=2‐phenylpyridine) and their applications in X‐ray‐induced photodynamic therapy (X‐PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X‐rays and transfer energy to Irbpy(ppy) 2 + or Ru(bpy) 3 2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X‐rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X‐PDT to afford superb anticancer efficacy.
Lan et al. (Sun,) studied this question.