Key result
Pre-clinical loading with aspirin and heparin in out-of-hospital cardiac arrest patients was associated with increased survival to hospital discharge (56.3% vs 40.3%, p=0.008).
Why the study?
Despite frequent pre-hospital loading with antiplatelets and anticoagulants due to high rates of coronary occlusion, OHCA patients often have non-cardiac causes and high bleeding susceptibility, leaving an evidence gap.
Does pre-clinical loading with aspirin and unfractionated heparin improve survival and neurological outcomes in patients with out-of-hospital cardiac arrest?
Population
272 patients from an all-comer OHCA registry
Comparison
Pre-clinical loading with ASA and UFH vs no loading
Design
Retrospective cohort registry analysis
Follow-up
To hospital discharge
Authors
Loading...
Prehospital aspirin-heparin loading was associated with higher OHCA survival; hypothesis-generating and requires prospective RCTs before practice change.
Cohort (n=272)
Does pre-clinical loading with aspirin and unfractionated heparin improve survival and neurological outcomes in patients with out-of-hospital cardiac arrest?
Absolute Event Rate: 56.3% vs 40.3%
p-value: p=0.008
Pre-clinical loading with aspirin and unfractionated heparin in OHCA patients is associated with improved survival and neurological outcomes without increasing bleeding, though current practice shows significant mismatch with final ischemic diagnoses.
Macherey‐Meyer et al. (2023) conducted a cohort in Out-of-hospital cardiac arrest (OHCA) (n=272). Pre-clinical loading with aspirin (ASA) and unfractionated heparin (UFH) vs. No pre-clinical loading was evaluated on Survival to hospital discharge (p=0.008). Pre-clinical loading with aspirin and heparin in out-of-hospital cardiac arrest patients was associated with increased survival to hospital discharge (56.3% vs 40.3%, p=0.008).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: