Why the study?
How do elevated circulating non-esterified fatty acids contribute to glucose intolerance in Type 2 diabetes mellitus?
Population
Type 2 diabetes mellitus (pathogenesis models)
Design
Review
Authors
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Supports NEFA as a driver of beta-cell dysfunction and insulin resistance in T2DM; leaves open whether lowering NEFA improves outcomes.
How do elevated circulating non-esterified fatty acids contribute to glucose intolerance in Type 2 diabetes mellitus?
This review highlights the mechanisms by which elevated non-esterified fatty acids contribute to the pathogenesis of Type 2 diabetes through impaired insulin secretion and glucose disposal.
Paolisso et al. (1998) studied this question.
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