Key result
Live pentavalent rotavirus vaccine caused vaccine-acquired rotavirus infection, presenting as dehydration and diarrhea, in three infants subsequently diagnosed with severe combined immunodeficiency.
Why the study?
Does live pentavalent human-bovine reassortant rotavirus vaccine cause vaccine-acquired rotavirus infection in infants with severe combined immunodeficiency?
Case Report (n=3)
Does live pentavalent human-bovine reassortant rotavirus vaccine cause vaccine-acquired rotavirus infection in infants with severe combined immunodeficiency?
Live rotavirus vaccine can cause severe vaccine-acquired rotavirus infection in infants with severe combined immunodeficiency, raising safety concerns for this population.
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May warrant caution with live rotavirus vaccine pending SCID evaluation; hypothesis-generating for pre-vaccination immunodeficiency screening.
Patel et al. (2010) conducted a case report in Severe Combined Immunodeficiency (n=3). Live pentavalent human-bovine reassortant rotavirus vaccine was evaluated on Vaccine-acquired rotavirus infection. Live pentavalent rotavirus vaccine caused vaccine-acquired rotavirus infection, presenting as dehydration and diarrhea, in three infants subsequently diagnosed with severe combined immunodeficiency.
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