Live pentavalent rotavirus vaccine caused vaccine-acquired rotavirus infection, presenting as dehydration and diarrhea, in three infants subsequently diagnosed with severe combined immunodeficiency.
Case Report (n=3)
Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.
Patel et al. (Wed,) conducted a case report in Severe Combined Immunodeficiency (n=3). Live pentavalent human-bovine reassortant rotavirus vaccine was evaluated on Vaccine-acquired rotavirus infection. Live pentavalent rotavirus vaccine caused vaccine-acquired rotavirus infection, presenting as dehydration and diarrhea, in three infants subsequently diagnosed with severe combined immunodeficiency.