Microwave‐Actuated Hot‐Carrier/Polarization Triggers Catalysis to Coordinate Staphylococcus aureus Ribosome Stalling and Treat Deep‐Seated Infections

Abstract Due to the low energy of microwaves (MW), MW dynamic therapy (MWDT) remains inefficient in treating deep‐seated infections. Here, an MW‐actuated hot‐carrier/polarization‐triggers catalysis strategy is proposed via two types of tandem reactors to amplify the efficacy of MWDT. By combining MW‐thermosensitive carbon nanotube (CNT) with thermal‐electricity conversion materials, the Seebeck‐type and pyroelectric‐type MW‐thermal‐electricity tandem reactors (CNT‐Bi 2 Te 3 and CNT‐ZnO) are prepared. The CNT converts MW into a local heat source and rapidly heats Bi 2 Te 3 or ZnO to activate hot‐carrier or polarization for high‐yield reactive oxygen species production to treat deep‐seated infections. Transcriptomic and metabolomic analyses reveal MW stalls the ribosomes of Staphylococcus aureus , thereby hindering its proliferation. Therefore, the biocompatible tandem reactor synergizes with bacterial ribosome stalling to demonstrate a targeted bactericidal effect in vivo and in vitro. Furthermore, a series of antimicrobial products is developed for precise and efficient antimicrobial therapies.