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April 1, 1997AJP Cell Physiology

Tissue specificity and alternative splicing of the Na+/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat

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Population

Rat tissues and cells, including selected tissues from neonatal and adult rats, and cultured cortical…

Design

Preclinical

Authors

BQBeate D. QuednauDNDebora A. NicollKPKenneth D. Philipson

Discussion

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Overview

These rat isoforms are hypothesis-generating; leaves open their functional roles and therapeutic relevance in human cardiovascular disease.

Structured PICO

P
Population
Rat tissues and cells, including selected tissues from neonatal and adult rats, and cultured cortical neurons, astrocytes, and oligodendrocytes
I
Intervention
Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of splicing isoforms
O
Outcome
Identification and tissue distribution of splicing isoforms of NCX1, NCX2, and NCX3surrogate

The study identifies novel splicing isoforms of Na+/Ca2+ exchangers NCX1 and NCX3 in rats, demonstrating tissue-specific expression and developmental regulation.

Cite This Study

Quednau et al. (1997) studied this question.

synapsesocial.com/papers/6a7beef2a540d02696c2ae32https://doi.org/10.1152/ajpcell.1997.272.4.c1250
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