The dengue viruses are currently the most important viruses transmitted to humans by mosquitoes. Intensive urbanisation, exploitation of man-made breeding sites by Aedes vector mosquitoes, and the development of efficient transport allows rapid movement of infected humans, introducing the viruses to new areas. This has resulted in a rapidly rising incidence of dengue viruses globally. Although there is a large body of published scientific information on these viruses, it is often difficult to obtain. This book aims to give a comprehensive coverage of many aspects of dengue and severe dengue haemorrhagic fever, to identify current issues, and to stimulate much-needed research towards effective control. The book comprises 20 chapters and is divided into four sections: Part 1, Natural History, covers the history of dengue and its resurgence as a global problem, epidemiology, mosquitoes and virus-vector relationships and factors influencing transmission dynamics. Part 2, Clinical Aspects and Treatment, deals with the clinical spectrum of dengue infection, the pathology of dengue infections and diagnosis and management. Part 3, The Viruses and the Immune Response, deals with the taxonomy and evolutionary relationships of flaviviruses, molecular biology of dengue viruses, immunochemistry of the dengue viruses, antibody responses to infection, viral pathogenesis, immunopathogenesis, immunosuppression and cytotoxicity, laboratory diagnosis, and molecular techniques in laboratory diagnosis. The final section (Part 4), on prevention and control, focuses on the live attenuated dengue vaccine, recombinant dengue vaccines, surveillance and urban mosquito control. All the chapters are accurate, up-to-date, and authorative reviews written by specialists. No matter what your own particular speciality – be it clinical, virological, molecular, epidemiological, entomological or control – there is a wealth of factual information here. Overall, this book is a very valuable contribution to the study of dengue and I recommend it without hesitation.
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Leake et al. (1998) studied this question.