Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma

Phyllodes tumors (PTs) are rare primary biphasic neoplasms of the breast that account for up to 1% of breast tumors.1 PTs can be classified as benign, borderline, or malignant. Malignant PTs, which comprise less than 25% of all cases, exhibit high-grade histologic features, including marked stromal atypia, hypercellularity, high mitotic activity, stromal overgrowth, and infiltrative borders.1,2 The concept of “giant PT” (>10 cm) is associated with an increased propensity for the development of local recurrence (LR) and distant metastases.