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Inwardly rectifying potassium channels typically rely on extrinsic polyamine block for voltage dependence, but polyamine-independent gating in Kir4.1/Kir5.1 heteromeric channels suggested an alternative mechanism involving permeating ions.
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Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with permeating ions.
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Harley T. Kurata (2021) studied this question.
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