Reagent‐Installed Capsule Network: Selective Thiocarbamoylation of Aromatic Amines in Crystals with Preinstalled CH₃NCS

Crystalline reagent capsules were prepared by installing CH3NCS into networked molecular capsules. While the tight encapsulation completely prevented leaching of reagent molecules into the supernatant, introduction of amines into the interstitial pores triggered reagent delivery. As a result, enhanced substrate selectivity was observed in crystalline-state thiocarbamoylation (see picture; 86:14 in favor of 2- vs. 1-naphthylamine).