Angiolymphoid hyperplasia with eosinophilia can present in lymph nodes and mimic Hodgkin's disease, highlighting the need to include it in differential diagnoses for eosinophilic infiltrates.
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Include nodal AHE in eosinophilic lymphadenopathy differentials; extends recognized spectrum but leaves open validation beyond single cases.
Angiolymphoid hyperplasia with eosinophilia (AHE) is a benign process of unknown origin that tends to mainly affect the skin and subcutaneous tissue. A case is presented of AHE arising in a lymph node in the absence of dermal or subcutaneous involvement. The unusual location and histologic characteristics of the lesion prompted an initial diagnosis of Hodgkin's disease. Follow-up and review of the biopsy at a later date disclosed the characteristic features of AHE. The present case illustrates the ubiquitous nature of this process. AHE should be included in the differential diagnosis in lymph nodes showing effacement of their architecture by a diffuse, predominantly eosinophilic cellular infiltrate.
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Saul Suster (1987) studied this question.
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