Use of Vinblastine Sulfate to Treat Hodgkin's Disease During Pregnancy

Case Studies1 July 1964Use of Vinblastine Sulfate to Treat Hodgkin's Disease During PregnancyMORTIMER J. LACHER, M.D.MORTIMER J. LACHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-1-113 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the constant use of new chemotherapeutic agents for treatment of cancer, it is inevitable that these agents will eventually be used during pregnancy. The urgent need to define the effect of these agents on the fetus has been amply illustrated by the experience with thalidomide (1, 2).The following case report illustrates the use of vinblastine sulfate (Velban_) in a pregnant patient with Hodgkin's disease.CASE REPORTA 22-year-old white female first noted a lump in the left neck in October, 1961. In March, 1962, a left cervical node biopsy was diagnosed as Hodgkin's granuloma. A chest X ray...References1. LENZ W: Thalidomide and congenital abnormalities. Lancet I: 45, 1962. CrossrefGoogle Scholar2. MCBRIDE WG: Thalidomide and congenital abnormalities. Lancet II: 1358, 1961. CrossrefGoogle Scholar3. BARRYDIAMONDCRAVER RMHDLF: Influence of pregnancy on the course of Hodgkin's disease. Amer. J. Obstet. Gynec. 84: 445, 1962. CrossrefMedlineGoogle Scholar4. HENNESSYROTTINO JPA: Hodgkin's disease in pregnancy with a report of twelve cases. Amer. J. Obstet. Gynec. 63: 756, 1952. CrossrefMedlineGoogle Scholar5. HENNESSYROTTINO JPA: Hodgkin's disease in pregnancy. Amer. J. Obstet. Gynec. 87: 851, 1963. CrossrefMedlineGoogle Scholar6. SMITHSHEEHYROTHBERG RBTWH: Hodgkin's disease and pregnancy. Arch. Int. Med. (Chicago) 102: 777, 1958. CrossrefGoogle Scholar7. SOKALLESSMANN JEEM: Effects of cancer chemotherapeutic agents on the human fetus. JAMA 172: 1765, 1960. CrossrefMedlineGoogle Scholar8. ARMSTRONGDYKEFOUTSJANSEN JGRWPJCJ: Delivery of a normal infant during the course of oral VLB therapy for Hodgkin's disease. Ann. Intern. Med. 60: 106, 1964. LinkGoogle Scholar9. MACMAHON B: Prenatal x-ray exposure and childhood cancer. J. Nat. Cancer Inst. 28: 1173, 1962. MedlineGoogle Scholar10. FERM VH: Congenital malformation in hamster embryos after treatment with vinblastine and vincristine. Science 141: 426, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MORTIMER J. LACHER, M.D.Affiliations: New York, New YorkFrom the Lymphoma Service, Department of Medicine, Memorial Hospital for Cancer and Allied Diseases, and the James Ewing Hospital of the City of New York, New York City, New York.Requests for reprints should be addressed to Mortimer J. Lacher, M.D., Memorial Hospital for Cancer and Allied Diseases, 444 East 68th Street, New York, New York, 10021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVinca alkaloidsManagement of Hematologic Malignancies: Special Considerations in Pregnant WomenCancer chemotherapeutic agents as human teratogensDRUGS USED IN CANCER CHEMOTHERAPYChallenging Problems: Coincident Pregnancy, HIV Infection, and Older AgeVinca alkaloidsCytostatic drugsAdverse Reproductive Outcome Potential of Cancer Therapies During PregnancySuccessful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancyCytotoxic drugs in pregnancyManagement of the Pregnant Patient with Hodgkin's DiseaseCHARLOTTE JACOBS, M.D., SARAH S. DONALDSON, M.D., SAUL A. ROSENBERG, M.D., HENRY S. KAPLAN, M.D.Pregnancy outcome of patients treated for Hodgkin's disease.A controlled studyGenetic and related effects of Vinca rosea alkaloidsMultiple agent chemotherapy including bleomycin of non-hodgkin's lymphoma during pregnancyToxicity of Antineoplastic Agents in Man: Chromosomal Aberrations, Antifertility Effects, Congenital Malformations, and Carcinogenic PotentialImmunosuppressive and Cytotoxic Chemotherapy: Long-Term ComplicationsPHILIP S. SCHEIN, M.D., F.A.C.P., M.R.C.P., STANLEY H. WINOKUR, M.D.Effects of vinblastine and podophyllin on DBA mouse fetusesCombination chemotherapy in malignant diseaseBiological Activity of the Terpenoids and Their Derivatives — Recent AdvancesDiagnosis and Therapy of Malignant Lymphoma during PregnancySevere Vinblastine-Induced Leukopenia During Late Pregnancy with Delivery of a Normal InfantJAMES J. NORDLUND, M.D., VINCENT T. DEVITA, M.D., PAUL P. CABBONE, M.D.HODGKIN'S DISEASE AND PREGNANCYCYTOTOXIC DRUGS IN PREGNANCY. Review of Reported CasesSPECIAL PROBLEMS IN TOXICITY 1 July 1964Volume 61, Issue 1Page: 113-115KeywordsCancer treatmentFetusesHodgkin lymphomaHospital medicinePatientsPregnancySulfatesTachycardiaTachypneaThorax ePublished: 1 December 2008 Issue Published: 1 July 1964 PDF downloadLoading ...