Infective Endocarditis Hospitalizations in Kentucky, 2008-2018: Spatial and Temporal Trends

August 10, 2026Open Access

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Key Points

This study examines trends in infective endocarditis hospitalizations in Kentucky from 2008 to 2018, focusing on the impact of opioid use.
Analyzed hospital data from 2008-2018 for residents 18+ in Kentucky.
Identified admissions using ICD-9 & 10 codes and calculated rates using U.S. Census data.
Performed spatiotemporal cluster analysis with Poisson modeling and Joinpoint regression.
17,787 total infective endocarditis hospital admissions observed, 3,577 associated with intravenous drug use (IDU-IE).
IDU-IE hospitalization rates increased from 1.2 to 27.3 per 100,000 from 2008 to 2018.
Joinpoint regression showed a significant upward trend for IDU-IE (APC 71.3%, 95% CI: 47.8, 98.5) from 2013-2018.

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Reveals significant increases in infective endocarditis hospitalizations, especially among intravenous drug users in Kentucky.

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Marji et al. (2026) studied this question.

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