Key result
QDOT MICRO microelectrodes record ~130% higher local electrogram voltages at conduction gaps versus conventional electrodes.
Why the study?
Residual conduction gaps hinder first-pass success and lead to arrhythmia recurrence after pulmonary vein isolation, but the utility of the QDOT MICRO catheter microelectrodes in detecting these gaps needed evaluation.
Does electrogram recording using microelectrodes improve the detection and characterization of conduction gaps during pulmonary vein isolation compared to conventional 3.5-mm tip electrodes in patients with atrial fibrillation?
Observational (n=40)
Does electrogram recording using microelectrodes improve the detection and characterization of conduction gaps during pulmonary vein isolation compared to conventional 3.5-mm tip electrodes in patients with atrial fibrillation?
Answers are grounded in this paper and cite their sources.
The use of microelectrodes significantly amplifies local electrogram voltage and improves the detection of fragmented potentials at conduction gaps during pulmonary vein isolation compared to conventional electrodes.
Background Pulmonary vein isolation (PVI) remains a cornerstone treatment for atrial fibrillation; however, residual conduction gaps often hinder first‐pass success and contribute to late reconnection, leading to arrhythmia recurrence. The QDOT MICRO catheter (Biosense Webster Inc., CA, USA) is equipped with three microelectrodes at its tip. Their small size and short inter‐electrode spacing allow for a more detailed recording of intracardiac potentials. This study evaluated the utility of the QDOT MICRO catheter in detecting conduction gaps during PVI. Methods Forty‐four gaps in 40 patients undergoing initial PVI were analyzed by comparing electrograms recorded using microelectrodes and conventional 3.5‐mm tip electrodes. Results At the gap sites, the local electrogram voltage recorded by microelectrodes was significantly higher than that by 3.5‐mm tip electrodes (median, 0.449 vs. 0.195 mV, p < 0.001), representing a 2.3‐fold amplification. The prevalence of fragmented potentials at the gap sites was significantly higher with microelectrodes than with 3.5‐mm tip electrodes (61% vs. 30%, p < 0.001). In 36% of gaps, fragmented potentials were detected with microelectrodes, whereas the 3.5‐mm electrodes recorded nonfragmented signals, contributing to accurate gap detection. In 11% of gaps, the amplitude was extremely low with 3.5‐mm tip electrodes [median 0.107 (IQR 0.088–0.112) mV], rendering the interpretation of local electrogram challenging. However, microelectrodes amplified the signal [median 0.215 (IQR 0.176–0.283) mV], allowing for accurate identification and interpretation. Conclusion Microelectrodes enhance the detection and characterization of conduction gaps, particularly under low‐voltage or in scarred tissue, thereby improving ablation accuracy.
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Masuda et al. (2026) conducted an observational in Atrial fibrillation (n=40). QDOT MICRO catheter (microelectrodes) vs. Conventional 3.5-mm tip electrodes was evaluated on Local electrogram voltage at gap sites (mV) (p=<0.001). The QDOT MICRO catheter microelectrodes recorded significantly higher local electrogram voltages at conduction gaps compared to conventional 3.5-mm tip electrodes (median 0.449 vs 0.195 mV, p<0.001).
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